The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.

Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MRG, Hewitson KS, Oldham NJ, Schofield CJ

Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.

Keywords:

Carboxylic Acids

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Models, Molecular

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Oxygenases

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Protein Biosynthesis

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Protein Structure, Tertiary

,

Repressor Proteins

,

Transcription Factors