The synthesis and likely conformational structure of rigid spirocyclic bislactams and lactam-lactones derived from pyroglutamic acid, and their suitability as lead structures for applications in drug development programmes using cheminformatic analysis, has been investgated.
Keywords:
Cyclization
,Lactams
,Lactones
,Models, Molecular
,Molecular Structure
,Pyrrolidonecarboxylic Acid
,Spiro Compounds
