Designing secondary structures: 5-azidomethyl tetrahydrofuran-2-carboxylates as carbohydrate-derived dipeptide isosteres.

Smith MD, Fleet GW

The potential of carbohydrate-like tetrahydrofuran frameworks as building blocks with predictable conformational propensities useful in the design and synthesis of novel peptidomimetic materials which adopt well-defined secondary structures is discussed.

Keywords:

Amino Acids

,

Biochemistry

,

Carbohydrates

,

Drug Design

,

Furans

,

Models, Molecular

,

Molecular Conformation

,

Molecular Mimicry

,

Molecular Structure

,

Peptides

,

Protein Structure, Secondary