Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.
Keywords:
Aspirin
,Dioxygenases
,Enzyme Inhibitors
,Hypoxia-Inducible Factor 1, alpha Subunit
,Molecular Structure
,Spectrometry, Mass, Electrospray Ionization
