Lab-chip HPLC with integrated droplet-based microfluidics for separation and high frequency compartmentalisation.

Kim J-Y, Cho S-W, Kang D-K, Edel JB, Chang S-I, deMello AJ, O'Hare D

We demonstrate the integration of a droplet-based microfluidic device with high performance liquid chromatography (HPLC) in a monolithic format. Sequential operations of separation, compartmentalisation and concentration counter were conducted on a monolithic chip. This describes the use of droplet-based microfluidics for the preservation of chromatographic separations, and its potential application as a high frequency fraction collector.

Keywords:

Fluorescein-5-isothiocyanate

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Fluorescent Dyes

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Chromatography, High Pressure Liquid

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Microfluidic Analytical Techniques

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Equipment Design