Deprotonation-electrophile trapping of terminal epoxides.

Hodgson DM, Kirton EHM, Miles SM, Norsikian SLM, Reynolds NJ, Coote SJ

Organolithium-induced deprotonation of terminal epoxides in the presence of appropriate diamine ligands allows trapping with a range of electrophiles, yielding functionalised di- and tri-substituted epoxides in good yields and with control of stereochemistry at the epoxide.

Keywords:

Epoxy Compounds

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Magnetic Resonance Spectroscopy

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Mass Spectrometry

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Protons

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Spectrophotometry, Infrared